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Minor side effects can include: A bit of tenderness, puffiness, or pink discoloration right around the puncture A brief warm or flushed sensation Mild headache or nausea Reach out to a medical professional right away if you notice: Redness that keeps spreading, heat, or discharge near the site (possible infection) Hives, facial swelling, or difficulty breathing (possible allergic reaction) Persistent numbness or tingling that spreads beyond the site Fever or chills within 48 hours of injection Safe Needle Disposal and Storage A proper FDA-cleared sharps bin is ideal
Its key for those with severe deficiencies or long-term symptoms
Because it competes at the nicotinamide substrate site rather than the SAM cofactor site, it is also used as the substrate-competitive reference compound against which bisubstrate and covalent NNMT inhibitors are benchmarked
However, while B12 shots are safe for many, they may not be suitable for everyone
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