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Increased Serum Sclerostin and Decreased Serum IGF-1 Are Associated With Vertebral Fractures Among Postmenopausal Women With Type-2 Diabetes

Cochrane-standard systematic reviews have examined the randomized controlled trial data across multiple GLP-1 medications, and the weight of the published evidence supports the conclusion that in properly selected patients, GLP-1 receptor agonists produce clinically meaningful weight loss that exceeds what diet and exercise alone typically achieve without pharmacological support

If youve tried every diet trick without lasting success, this may be the tool that finally works in your favor, not against inbuilt quirks of metabolism

Additionally, some insurers are implementing step therapy and BMI or comorbidity requirements to slow utilization and restrict inappropriate use