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The primary concerns revolve around potential overlapping gastrointestinal side effects such as nausea, vomiting, diarrhea, or constipation, which both medications can cause

However, these effects are relatively small compared with other pharmacologic treatments for obesity, such as GLP-1 receptor agonists (e.g., semaglutide), which produce greater and more sustained weight loss and improvements in glycemic control

Patients with highly responsive variants may experience stronger nausea initially, suggesting higher baseline hydration needs

Kojic acid reduces the activity of tyrosinase, which can reduce hyperpigmentation, melasma, and dark spots by limiting the production of too much melanin