always cold on tirzepatide Mounjaro and Feeling Does Mounjaro make you feel

A 2025 systematic review and meta-analysis in Reviews in Endocrine and Metabolic Disorders found that tirzepatide (the active ingredient in Mounjaro and Zepbound) reduced hsCRP by approximately 33% and IL-6 by approximately 18% compared to placebo across patients with and without diabetes. A growing body of research suggests this effect occurs through direct action on the NF-B pathway, a master switch of inflammation

Guo Z, Ran Q, Roberts LJ 2nd, Zhou L, Richardson A, et al

Your healthcare provider might suggest spacing doses at specific times to avoid complications

Inhibition of platelet MAO-B by the antidepressant and anti Parkinson drug selegiline: biochemical and clinical aspects