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Traditional weight loss interventions like very-low-calorie diets, behavioral modification programs, and over-the-counter supplements have a substantially weaker evidence base than prescription GLP-1 medications for sustained, clinically significant weight loss that persists beyond the active intervention period - a distinction that matters when you're evaluating whether a monthly subscription to a medication program is a better long-term value than another round of a protocol you've already tried and discontinued

Kobalava, Z