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OTHER EMERGING PHARMACOLOGIC STRATEGIES Glucagon-like peptide-1 (GLP-1) receptor agonists, such as liraglutide and semaglutide, have emerged as promising therapies with extensive metabolic, cardiovascular, and renal benefits.77, 78 These agents stimulate endogenous GLP-1 to enhance glucose-dependent insulin secretion, suppress glucagon secretion, slow gastric emptying, and promote satiety, leading to significant weight loss.79 The STEP trials demonstrated that semaglutide induces substantial and sustained weight loss, improving metabolic health and reducing obesity-related complications.80 Since central obesity and insulin resistance are core components of CMS, GLP-1 receptor agonists represent a key therapeutic option for modifying disease progression

Obesity and weight loss in idiopathic intracranial hypertension: a narrative review, 2017

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