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Insufficient fluid intake with fibre supplements can lead to intestinal obstruction, oesophageal blockage, or worsening constipationrisks that are heightened by the slowed gastric emptying from GLP-1 therapy

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The gastrointestinal effects are dose-dependent, which explains why symptoms often emerge or worsen when doses are increased according to standard titration schedules

Verma S, Poulter NR, Bhatt DL et al (2018) Effects of liraglutide on cardiovascular outcomes in patients with type 2 diabetes mellitus with or without history of myocardial infarction or stroke