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However, individual responses to medications vary between individuals

doi: 10.1016/j.tem.2012.11.008

Surgical revisions such as a repeat surgical sleeve or conversion to a Roux-en-Y gastric bypass (from laparoscopic sleeve gastrectomy) carry a higher morbidity risk than the initial surgery, but endoscopic revisional procedures have lower adverse event rates than surgical revision

They act on both central and peripheral pathways